RESUMO
Melanoacanthoma is a rare variant of seborrheic keratosis, which is notable for dark pigmentation and fast radial growth, making it difficult to distinguish from melanoma. Histologically, it is characterized by proliferation of keratinocytes and dendritic melanocytes. The authors report a scalp lesion, fast growing, suspected by dermoscopy and confocal microscopy examination, with dendritic cells distributed throughout the lesion. Based on these findings, it was not possible to classify this lesion as clearly benign, so it was excised. Histopathologic evaluation and immunostain were consistent with melanoacanthoma.
Assuntos
Acantoma/patologia , Ceratose Seborreica/patologia , Dermatoses do Couro Cabeludo/patologia , Neoplasias Cutâneas/patologia , Idoso , Células Dendríticas/patologia , Dermoscopia , Humanos , Masculino , Melanócitos/patologia , Microscopia Confocal/métodosRESUMO
Abstract Melanoacanthoma is a rare variant of seborrheic keratosis, which is notable for dark pigmentation and fast radial growth, making it difficult to distinguish from melanoma. Histologically, it is characterized by proliferation of keratinocytes and dendritic melanocytes. The authors report a scalp lesion, fast growing, suspected by dermoscopy and confocal microscopy examination, with dendritic cells distributed throughout the lesion. Based on these findings, it was not possible to classify this lesion as clearly benign, so it was excised. Histopathologic evaluation and immunostain were consistent with melanoacanthoma.
Assuntos
Humanos , Masculino , Idoso , Dermatoses do Couro Cabeludo/patologia , Neoplasias Cutâneas/patologia , Ceratose Seborreica/patologia , Acantoma/patologia , Células Dendríticas/patologia , Microscopia Confocal/métodos , Dermoscopia , Melanócitos/patologiaRESUMO
In the 1980s, the increasing incidence of skin cancers prompted the development of noninvasive medical devices to improve skin cancer diagnosis in daily dermatology practice. As a result of the development of these noninvasive techniques, diagnosis is now established earlier and with better accuracy. These advances are of great benefit to high-risk patients, who previously would have had to undergo several excisions. In this review, we focus on the classic technique of dermoscopy and the more recent digital version, as well as on advanced noninvasive imaging techniques, such as reflectance confocal microscopy and optical coherence tomography. On the basis of their specific features, these noninvasive medical devices can be used not only to diagnose and monitor melanoma and nonmelanoma skin cancers but also to choose the best therapy and follow the patient's response to treatment in vivo.
Assuntos
Dermatologia/métodos , Oncologia/métodos , Neoplasias Cutâneas/diagnóstico por imagem , Dermatologia/instrumentação , Dermoscopia/instrumentação , Dermoscopia/métodos , Humanos , Oncologia/instrumentação , Microscopia Confocal/instrumentação , Microscopia Confocal/métodos , Fotoquimioterapia/métodos , Cuidados Pré-Operatórios/métodos , Prognóstico , Pele/diagnóstico por imagem , Neoplasias Cutâneas/terapia , Tomografia de Coerência Óptica/instrumentação , Tomografia de Coerência Óptica/métodos , Resultado do TratamentoRESUMO
Treatment options for advanced stage cutaneous T-cell lymphoma (CTCL) are limited by the their efficacy and side-effects profile. Gemcitabine, a pyrimidine analogue, has been reported to be efficacious in CTCL. Most of the studies published used gemcitabine as a single agent in treating advanced CTCL. Our small case series demonstrated that a combination of gemcitabine and vinorelbine induced partial remission in all four patients with refractory or advanced CTCL, although the effects were not sustained for a long duration (2-6 months). Two patients had neutropenia and one had acute hepatitis, requiring discontinuation of treatment.
